Unfortunately my go-to program is Clip Studio Paint, which is pretty mainstream. So was the program I used before it, Paint Tool Sai/Sai 2. But I do have some experience with this.
- AzPainter 2 is a program I tried before and want to get back into. It's primitive but the tools allow you to make sort of old oekaki-ish type art. I have no idea how else to explain it.
- GIMP. Bad name, okay editor. For several years I used an outdated Mac given to me by family, and I couldn't really run anything good back in the early 2010s... So GIMP was my go-to.
- Colors 3D is REALLY GOOD. The 3DS version, at least. It was the reason I got a 3DS a decade ago, it's a good application and I loved it. If my 2DS could charge, I'd still use it today. I own the Switch version, but despite being better I haven't really broken into it... Especially when the stylus is bent and I'd have to get a new one. Ugh.
- For another art-related 3DS game, Art Academy is decent. I actually quite enjoyed the lessons in the game and they helped me with painting with real media, ironically.
- I dabbled in Artrage for awhile back when I used a Mac, albeit a trial version. It's a decent digital program that emulates real paint.
- For a modern "real media emulation" program, Rebelle 7 fits the bill. It's very good on a technical level, but I personally didn't like it.
- Dotpict is a decent free pixel art editor for mobile.