The main one I'm waiting for is Pony Island 2: Panda Circus. It's made by the same person who did The Hex, Inscryption, and Pony Island (obviously), all of which are great games, and all of the teasers so far look really good.
Another big one for me is Desktop Explorer. I was luckily early enough to find this game to be a play tester, and the demo is really enjoyable. The sort of "computer simulator" genre has already started to be pretty well explored, but this just seems like a really solid execution of the premise.
There's also Last Look along Woodward Boulevard, which was made by the person who made on of my favorite games, Who's Lila?. There's a demo out, but I haven't played it because I want to be fully surprised.
The last one is that a follow up to imscared called Remnants of a Scare was announced recently (though it's been being teased for a while if you know where to look). imscared has aged surprisingly well for what it is in my opinion, and I can't wait to see what this game is like.